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Name: where is melanotan legal II, also known as 'The Barbie Drug,' an unregulated substance with serious reported side effects that is not safe for consumer use. The bottom line: Melanotan II has Melanotan I UK: Afamelanotide Evidence,
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10.1002/oby.22325 179

In this regard, in the recent years, new approaches including the recruitment of nanotechnology in targeted topical drug delivery have been considered to overcome these drawbacks and cause optimum clinical response (Salvioni et al., 2021) Therefore, different types of nanoparticles including lipid nanoparticles, nanoemulsion/microemulsion, vesicular nanocarriers, polymeric nanoparticles, nanocrystals, and metal nanoparticles have been used as topical drug delivery systems for melasma management